Mouse induced pluripotent stem cells
نویسندگان
چکیده
منابع مشابه
Mouse induced pluripotent stem cells.
The recent discovery that it is possible to directly reprogramme somatic cells to an embryonic stem (ES) cell-like pluripotent state, by retroviral transduction of just four genes (Oct3/4, Sox2, c-Myc and Klf4), represents a major breakthrough in stem cell research. The reprogrammed cells, known as induced pluripotent stem (iPS) cells, possess many of the properties of ES cells, and represent o...
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Regenerative capacity of mammals is limited and can rarely regenerate a specific organ or tissue fully. Due to these limitations, regenerative medicine seeks efficient and safe cell sources for regeneration of damaged tissues and organs or treatment for incurable diseases. Human embryonic stem cells (HESCs) hold two important properties called self renewal and pluripotency. However, the use of ...
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s session will also be offered on Tuesday morning. Back for its fourth year, the Special Symposium on the Basic Science of Hemostasis and Thrombosis with invited presentations by leaders in the field and simultaneous oral sessions will take place Tuesday morning and afternoon. In a recent Hematologist article, Dr. Bruce Furie discussed the history and rationale for the development of this speci...
متن کاملInduced pluripotent stem cells.
Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been possible with retroviral expression of the pluripotency-associated transcription factors Oct4, Sox2, Nanog, and Lin28 as well as Klf4 and c-Myc. iPS cells hold great potential as a model for diseases from the perspective of the individual patient and as an alternative source of pluripotent stem cel...
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Induced Pluripotent Stem Cells (iPSCs) are cells derived from non-pluripotent cells, such as adult somatic cells, that have been genetically manipulated so as to return to an undifferentiated, pluripotent state. Research on iPSCs, initiated by Shinya Yamanaka [5] in 2006 and extended by James Thompson in 2007, has so far revealed the same properties as embryonic stem cells [6] (ESCs), making th...
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ژورنال
عنوان ژورنال: The International Journal of Developmental Biology
سال: 2008
ISSN: 0214-6282
DOI: 10.1387/ijdb.082640eg